Osmosis Jones is a 2001 live-action/animated buddy cop comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are inside the live-action ones. It is set in a fictionalized version of the human body which resembles a large city, where micro-organisms or any being based in organisms are anthropomorphic and centers on Frank Detorre, a slovenly zookeeper. Osmosis Jones, a white blood cell, teams up with Drix, a cold pill, against Thrax, a deadly virus who plans to kill Frank in forty-eight hours and other characters living within him. It met with mixed reviews, and was a box office bomb, earning $14 million against a budget of $70 million. Despite the lack of accolades, the film sold well in home media. It was later adapted into a Saturday morning cartoon television show, Ozzy & Drix, which aired on Kids WB from 2002 to 2004, albeit being completely animated and more emphasis on Osmosis and Drix's partnership in a different body. Limited merchandise was created due to the film's financial failure.